Scientific Advisory Board

Joseph DeAngelo, M.S.

Mr. DeAngelo is Vice President of Research and Chief Scientific Officer for Apex Bioscience, the US subsidiary of Curacyte AG and a member of Curacyte Vorstand. He was one of the founding scientists of Apex Bioscience and is an expert in yeast biology. Mr. DeAngelo is an inventor of eleven issued patents. He has been active for over ten years in the field of nitric oxide biology and is a well-recognized expert in the field. Under his direction, Apex’s lead product, PHP, a hemoglobin-based nitric oxide scavenger, was developed from pre-phase 1 to phase 3 clinical trials. Mr. DeAngelo received both his undergraduate and graduate training at the Massachusetts Institute of Technology.

David Bramhill, Ph.D.

Dr. Bramhill has more than 20 years of experience in R&D, business development and licensing in biotechnology. He was Associate Director at Merck Research Laboratories for 14 years where he led evaluation of all technology platforms required for discovery and development of therapeutic monoclonal antibodies, including humanized mice and phage display libraries. His team produced HIV proteins for vaccine development and he coordinated a multinational team developing new antibody-eliciting vaccine for HIV (6 locations in US, Europe and Asia). As a director of licensing for RCT, he managed out-licensing programs covering platform technologies, including Pichia yeast expression technology. He completed more than 50 licenses generating multimillion-dollar revenues from 2007-2012. Dr. Bramhill also developed IP strategies and is co-inventor of technologies related to protein engineering and protein expression. He received his M.A. degree from Cambridge University and Ph.D. from Newcastle University in the UK. He completed his post-doctoral fellowship in the laboratory of Nobel laureate Arthur Kornberg at Stanford University.

Michael Holland, Ph.D.

Prof. Holland is a Professor of Biochemistry and Molecular Medicine at University of California, Davis. He started his career in biotechnology when he was a postdoctoral fellow with Dr. William Rutter (former CEO & founder of Chiron) at the University of California. Prof. Holland is an expert in the yeast molecular biology and is a pioneer in the area of expression of proteins in yeast. He has been a consultant for several biotech companies including Chiron, Roche and Apex Bioscience. His current research involves the application of novel functional genomics approaches to understanding mechanisms of gene expression. Prof. Holland has been advisor for Dr. Motwani’s team at Apex Bioscience and later at BioSavita. He received his Ph.D. in Biochemistry from the University of Massachusetts.

Fred Winston, Ph.D.

Prof. Winston is a Professor of Genetics at Harvard Medical School. He is an expert in the areas of yeast genetics, transcriptional control, and chromatin structure. Prof. Winston began studies of yeast genetics and molecular biology as a postdoctoral fellow with Dr. Gerald Fink.

For over 20 years, his laboratory at Harvard has used yeast genetics to identify and study proteins critical for normal gene expression. These pioneering studies have led to several new insights concerning the roles of general transcription factors, chromatin remodeling complexes, histone proteins, and transcription elongation. Prof. Winston has been advisor for Dr. Motwani’s scientific team at Apex Bioscience and later at BioSavita. He received his Ph.D. in Biology from the Massachusetts Institute of Technology.